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Side effects of boron neutron capture therapy
1Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Journal of Cancer Research and Therapeutics
|September 4, 2025
Summary
Boron neutron capture therapy (BNCT) shows promise for cancer treatment but can cause side effects. Understanding these adverse events is key to improving BNCT safety and effectiveness for patients.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Boron neutron capture therapy (BNCT) is a binary cancer treatment targeting tumor cells.
- Clinical applications span various cancers like gliomas, head and neck cancers, and melanomas.
- Adverse effects of BNCT present challenges to its widespread clinical adoption.
Purpose of the Study:
- To systematically review adverse effects of BNCT from clinical studies.
- To analyze mechanisms, contributing factors, and tumor-specific variations in BNCT side effects.
- To highlight management strategies and identify future research needs for BNCT safety.
Main Methods:
- Systematic review of clinical studies on BNCT adverse effects.
- Analysis of reported side effects based on tumor type, neutron source, and boron delivery agents.
- Examination of treatment protocols and their impact on BNCT-related toxicities.
Main Results:
- BNCT-associated adverse effects vary significantly based on tumor type, neutron source, boron delivery agent, and treatment protocols.
- Mechanisms and contributing factors for these side effects were identified across different malignancies.
- Tumor-specific variations in adverse reactions were observed, impacting treatment outcomes.
Conclusions:
- Understanding BNCT adverse effects is crucial for optimizing treatment protocols.
- Current management and prevention strategies are discussed, alongside areas needing further investigation.
- This review supports the development of safer BNCT approaches for precision oncology.
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