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Updated: Sep 9, 2025

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

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Poly(Amic) Acid Copper Nanocubes as Biocide for Staphylococcus epidermidis.

Gaddi B Eshun¹, Francis J Osonga¹, Xueyan Zhang²

¹Department of Chemistry and Environmental Sciences, The BioSMART Center, New Jersey Institute of Technology, University Heights, Newark, New Jersey 07102, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|September 4, 2025

Summary

This summary is machine-generated.

We developed a method to grow copper nanocubes on polyamic acid films using applied potential, creating an effective biocide against resistant bacteria like Staphylococcus epidermidis.

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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Area of Science:

Materials Science
Nanotechnology
Electrochemistry

Background:

Biodegradable polymers offer sustainable platforms for advanced materials.
Controlling nanoparticle synthesis on polymer surfaces is crucial for tailored applications.
Copper nanoparticles exhibit potent antimicrobial properties.

Purpose of the Study:

To investigate the growth mechanism and pattern of copper nanocubes on polyamic acid films.
To explore the role of applied potential in controlling copper nanocube synthesis.
To evaluate the antibacterial efficacy of the synthesized copper nanocubes against resistant bacteria.

Main Methods:

Polyamic acid (PAA) film fabrication via polycondensation.
Electrochemical synthesis of copper nanocubes (CuNCs) using chronoamperometry.
Characterization using SEM, AFM, TEM, XPS, and DFT calculations.
Antibacterial activity assessment via time-kill assays against Staphylococcus epidermidis.

Main Results:

Successfully synthesized uniform copper nanocubes (4.59 nm ± 0.20) on PAA films.
Applied potential was identified as the key factor driving nucleation and growth.
Density Functional Theory (DFT) revealed favorable copper ion complexation with PAA carboxyl groups.
XPS confirmed the reduction of Cu²⁺ to Cu⁰ under applied potential.
PAA-CuNCs demonstrated 100% inhibition of Staphylococcus epidermidis, outperforming conventional CuNPs.

Conclusions:

Applied potential effectively controls the synthesis of copper nanocubes on PAA substrates.
The synthesized PAA-CuNCs exhibit significant antibacterial activity against resistant microbes.
Nanoparticle size and shape significantly influence antibacterial efficacy.
This work presents a promising approach for developing novel antimicrobial materials.