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Updated: Sep 9, 2025

Establishing 3D Endometrial Organoids from the Mouse Uterus
Published on: January 6, 2023
In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis
Grzegorz Mrugacz1, Aleksandra Mospinek2, Maria Modrzyńska-Olejniczak2
1Center for Reproductive Medicine Bocian, Białystok Branch, 26 Akademicka St., 15-267 Białystok, Poland.
Abstract:
Endometriosis significantly impacts fertility through complex mechanisms. These include chronic inflammation, oxidative stress, and anatomical distortion. These mechanisms impair oocyte quality, embryo development, and implantation. While in vivo challenges persist, in vitro fertilization (IVF) offers a controlled environment to overcome some barriers. A systematic review of evidence is presented for (1) endometriosis-associated oocyte dysfunction, (2) conflicting IVF outcomes, and (3) innovative strategies. Significant medical advancements have been made. However, gaps remain in personalized prognosis and targeted therapies. Emerging tools, specifically AI-driven embryo selection, single-cell omics, and immunomodulation, are promising for improving outcomes. Hence, a patient-centered approach, balancing science with personalized care, is essential to navigate endometriosis-related infertility.
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