Related Experiment Video
Updated: Sep 9, 2025
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
Preprocedural frailty status and short- and long-term mortality risk after endovascular therapy in elderly acute
Weiwei Gao1, Xingyu Chen2, Arslan Annadurdyyev3
1Department of Neurology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Objectives:
To evaluate the Laboratory-based Frailty Index (FI-LAB) for predicting mortality following endovascular therapy (EVT) in elderly patients with large vessel occlusion acute ischemic stroke (LVO-AIS).
Methods:
This retrospective study enrolled 382 patients aged ≥60 years undergoing EVT. FI-LAB was constructed using 44 preprocedural laboratory parameters. Primary endpoint was 12-month all-cause mortality; secondary endpoint was 14-day mortality. Cox proportional hazards models assessed FI-LAB-mortality associations.
Results:
Among 382 patients, 68.8% exhibited varying degrees of frailty. In fully adjusted models, compared with robust patients, frail patients demonstrated a 1.82-fold increase in 14-day mortality risk (P = 0.012) and a 2.61-fold increase in 12-month mortality risk (P < 0.001). Each 0.1-unit increase in FI-LAB was associated with a 51% increase in 14-day mortality risk (P = 0.001) and a 63% increase in 12-month mortality risk (P < 0.001).
Conclusions:
FI-LAB independently predicts short-term and long-term mortality following EVT in elderly stroke patients, offering objective risk stratification for clinical decision-making.
