Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

200
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
200
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

170
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
170
  1. Home
  3. Icg-fa For Anastomotic Leak Prevention During Minimally Invasive Colorectal Surgery: A Meta-analysis.
  1. Home
  3. Icg-fa For Anastomotic Leak Prevention During Minimally Invasive Colorectal Surgery: A Meta-analysis.

Related Experiment Video

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
07:51

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Published on: November 4, 2010

22.0K

ICG-FA for Anastomotic Leak Prevention During Minimally Invasive Colorectal Surgery: A Meta-analysis.

Muhammad Imran1, Shahr Yar2, Mansab Ali3

  • 1University College of Medicine and Dentistry, The University of Lahore, Lahore, Pakistan.

The Journal of Surgical Research
|September 4, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Indocyanine green fluorescence angiography (ICG-FA) significantly lowers anastomotic leakage and complications in minimally invasive colorectal surgery, particularly for left-sided procedures. However, it does increase operative time, and further research is needed for right-sided surgeries.

Keywords:
Anastomotic leakageColorectal surgeryFluorescence angiographyICGIndocyanine greenMeta-analysisMinimally invasive surgery

More Related Videos

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

13.8K
Creation of Colonic Anastomosis in Mice
07:22

Creation of Colonic Anastomosis in Mice

Published on: January 17, 2019

11.8K

Related Experiment Videos

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
07:51

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Published on: November 4, 2010

22.0K
An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

13.8K
Creation of Colonic Anastomosis in Mice
07:22

Creation of Colonic Anastomosis in Mice

Published on: January 17, 2019

11.8K

Area of Science:

  • Colorectal Surgery
  • Surgical Innovation
  • Medical Imaging

Background:

  • Anastomotic leakage is a critical complication following colorectal surgery.
  • Indocyanine green fluorescence angiography (ICG-FA) offers real-time perfusion assessment to potentially mitigate leak rates.
  • Conflicting results from recent large randomized clinical trials necessitate further investigation into ICG-FA's efficacy.

Purpose of the Study:

  • To evaluate the effectiveness of ICG-FA in reducing anastomotic leakage and related complications in minimally invasive colorectal surgery.
  • To synthesize evidence from randomized clinical trials to provide a clearer understanding of ICG-FA's impact.
  • To identify specific subgroups, such as left-sided or right-sided anastomoses, where ICG-FA may offer differential benefits.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases.
  • Relevant studies were screened for eligibility using Covidence.
  • Data from six randomized clinical trials (3264 participants) were synthesized using meta-analysis (RevMan 5.4) with risk ratios and 95% confidence intervals.

Main Results:

  • ICG-FA significantly reduced overall anastomotic leakage (RR: 0.66, P = 0.0005) and overall complications (RR: 0.88, P = 0.03).
  • A significant reduction in leakage was observed for left-sided anastomoses (RR: 0.57, P < 0.0001), but not for right-sided ones (RR: 0.90, P = 0.68).
  • No significant differences were found in severe complications (Clavien-Dindo ≥3), reoperation rates, or hospital stay; however, operative time was longer (MD: 5.57 min, P = 0.006).

Conclusions:

  • ICG-FA is effective in reducing anastomotic leakage and overall complications in minimally invasive colorectal surgery, especially for left-sided anastomoses.
  • The benefits of ICG-FA for right-sided anastomoses require further investigation.
  • While ICG-FA increases operative time, its role in improving surgical outcomes warrants consideration, with ongoing research needed for long-term effects.