Brain Metastasis From Angiosarcoma of the Scalp: Report of Three Cases

Brain metastasis from cutaneous angiosarcoma of the scalp is rare, and the characteristics and optimal treatment remain poorly understood. Herein, we report three cases of brain metastasis originating from cAS of the scalp. Case 1: An 81-year-old male developed lung metastasis 2.5 years after initial diagnosis, followed by brain metastasis 1 year later. He passed away 1 month after the detection of brain metastasis. Case 2: A 66-year-old male presented with lung and cervical lymph node metastases at the time of initial diagnosis. Brain metastasis was identified 5 months later after the onset of dizziness, and he passed away 2 months thereafter. Case 3: A 68-year-old male developed lung metastasis 7 months after initial diagnosis. Brain metastasis was detected 1 month later via computed tomography (CT). Palliative radiation therapy (30 Gy) led to a reduction in the size of the metastatic brain lesion; however, he passed away 2 months later. In each case, plain CT scans showed multiple high-density areas. The period from brain metastasis detection to death was uniformly short, within 2 months. These findings suggest that brain metastasis in cutaneous angiosarcoma of the scalp is associated with a poor prognosis.