Related Experiment Video
Updated: Sep 9, 2025
Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Associations of Current Cigarette, E-Cigarette, and Cannabis Use with Xerostomia
1University of California San Francisco, School of Dentistry, San Francisco, CA, USA.
Objectives:
This investigation aimed to examine the associations between xerostomia and the use of cigarettes, e-cigarettes, and cannabis in a nationally representative cross-sectional sample of adults.
Methods:
Data from the Population Assessment of Tobacco and Health Study included N = 29,721 United States adults (age ≥18 y) surveyed during 2022 to 2023 about xerostomia (experiencing dry mouth "frequently" or "always") and their use of 9 types of tobacco products and cannabis. Survey-weighted multivariable regression models estimated the associations of xerostomia with various specifications of cigarette, e-cigarette, and cannabis use, adjusted for sociodemographic and health status variables.
Results:
Overall, 9.7% of participants experienced xerostomia. In adjusted models, past 30-d use of cigarettes, e-cigarettes, and cannabis were each associated with greater odds of xerostomia. The daily use of cigarettes (adjusted odds ratio: 1.7; 95% confidence interval: 1.4, 2.0), e-cigarettes (1.8; 1.5, 2.2), and cannabis (2.1; 1.7, 2.7) was also associated with greater odds of xerostomia. The greatest odds of xerostomia was associated with the use of all 3 products in combination within the past 30 d (3.8; 2.8, 5.2).
Conclusions:
The use of cigarettes, e-cigarettes, or cannabis, particularly when used together, is associated with a greater occurrence of oral dryness among adults. Among other adverse health effects of these products, potential xerostomia risk may encourage cessation, contribute to dental patient advising, and inform appropriate tobacco and cannabis regulations and policies.Knowledge Transfer Statement:Based on the findings of this study, dental professionals and patients should anticipate a higher prevalence of xerostomia among adults who use cigarettes, e-cigarettes, and/or cannabis. Dental professionals should incorporate this information into xerostomia management, treatment planning, and the guidance and cessation support provided to patients who use these products. Potential adverse oral health effects should be considered in tobacco and cannabis policies and regulations.
More Related Videos
10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
08:39Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
01:29Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
01:26Stress Prevention and Stress Management Techniques IV
01:24Antiasthma Drugs: Methylxanthines
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
01:27CNS Depressants: Alcohol and Nicotine
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...