Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

526
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
526

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A mechanistic study on the enhanced antihypertensive effects of a <i>Dendrobium officinale</i> compound combined with Western antihypertensive drugs in spontaneously hypertensive rats based on metabolomics and gut microbiota analysis.

Frontiers in cell and developmental biology·2026
Same author

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same author

Mechanistic insights of hypoglycemic components from <i>Polygonatum</i> polysaccharide.

Frontiers in endocrinology·2026
Same author

Synergistic Effects of Compound Dendrobium Candidum and Antihypertensive Medications on Refractory Hypertension in Spontaneously Hypertensive Rats.

Cardiology research and practice·2026
Same author

Conformationally restricted pleuromutilins via a pyridinyl-amide tether bias peptidyl transferase center engagement enabling broad-spectrum potency against multidrug-resistant bacteria.

European journal of medicinal chemistry·2025
Same author

Hyperglycemia accelerated the metastasis of triple-negative breast cancer via promoting TNFα/Gli-1 axis in endothelial cells.

Biochimica et biophysica acta. General subjects·2025
Same journal

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

bioRxiv : the preprint server for biology·2026
Same journal

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026
Same journal

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in <i>Borrelia burgdorferi</i>.

bioRxiv : the preprint server for biology·2026
Same journal

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.

bioRxiv : the preprint server for biology·2026
Same journal

Structural and functional insights into the Rcs phosphorelay.

bioRxiv : the preprint server for biology·2026
Same journal

The structural basis of RanGAP1 regulation and catalysis in nuclear transport.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Sep 9, 2025

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.1K

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Wenbo Tang, Xiyu Mei, Ryan E Harvey

    Biorxiv : the Preprint Server for Biology
    |September 5, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Researchers discovered two types of brain cell sequences during navigation. One type predicts routes to remembered goals, revealing a flexible mechanism for memory-guided spatial navigation.

    More Related Videos

    Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents
    04:41

    Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

    Published on: December 2, 2022

    2.9K
    A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat
    08:37

    A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

    Published on: April 24, 2009

    11.9K

    Related Experiment Videos

    Last Updated: Sep 9, 2025

    Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
    06:17

    Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

    Published on: January 26, 2024

    2.1K
    Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents
    04:41

    Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

    Published on: December 2, 2022

    2.9K
    A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat
    08:37

    A Video Demonstration of Preserved Piloting by Scent Tracking but Impaired Dead Reckoning After Fimbria-Fornix Lesions in the Rat

    Published on: April 24, 2009

    11.9K

    Area of Science:

    • Neuroscience
    • Cognitive Science
    • Spatial Navigation

    Background:

    • Animals navigate complex environments using spatial memory.
    • The neural basis of memory-guided navigation is not fully understood.
    • Place cells in the hippocampus are crucial for spatial representation.

    Purpose of the Study:

    • To investigate the brain mechanisms supporting memory-guided navigation.
    • To identify how neural sequences encode trajectories in open environments.
    • To understand the coordination between hippocampal and prefrontal cortex activity during navigation.

    Main Methods:

    • Large-scale neural recordings in rats during navigation tasks.
    • Analysis of place cell sequences within theta oscillations.
    • Investigating neural replay during sharp-wave ripples.
    • Examining prefrontal cortex (PFC) and CA1 hippocampal circuit activity.

    Main Results:

    • Identified two distinct theta-cycle place cell sequences: stereotypic and goal-directed.
    • Goal-directed sequences predicted future trajectories to remembered locations.
    • These sequences were coordinated with PFC activity and replayed during sharp-wave ripples.
    • A CA1 circuit mechanism involving specific cell subpopulations and reduced inhibition generates goal-directed sweeps.

    Conclusions:

    • The brain employs distinct neural sequence types for different navigation demands.
    • Goal-directed sequences provide a flexible mechanism for memory-guided navigation.
    • Hippocampal-prefrontal interactions are critical for planning routes to remembered goals.