Related Experiment Video
Updated: Sep 9, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
Sevelamer-Associated Colitis as a Colon Cancer Mimicker
Brittany Doll1, Chandler Shapiro1, Zoë Post2
1Rush University Medical Center, Department of Internal Medicine, Chicago, Illinois.
None:
We reported a 40-year-old female patient with a history of end-stage renal disease on sevelamer who presented with acute microcytic on chronic normocytic anemia without overt signs of gastrointestinal (GI) bleeding. Colonoscopy was notable for a friable and ulcerated mass in the cecum concerning for malignancy. However, histopathology of biopsies demonstrated inflammatory and regenerative changes with fragments of crystalline material compatible with sevelamer crystals. This case report emphasizes the consideration of sevelamer crystal-induced GI mucosal injury with occult GI bleeding as etiology of worsening anemia in patients with chronic kidney disease.
More Related Videos
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...

