Diagnosis and Potential Therapy of Brain Diseases Using 64Cu: A Scoping Review

Area of Science:

• Nuclear Medicine
• Radiochemistry
• Neurology

Background:

• Copper radionuclides are increasingly explored for their dual diagnostic and therapeutic applications in medicine.
• Brain diseases present significant challenges, necessitating innovative diagnostic and therapeutic strategies.

Purpose of the Study:

• To comprehensively review the application of copper radionuclides, particularly 64Cu, in diagnosing and treating brain diseases.
• To assess the current status and future potential of copper isotopes in neuro-oncology and neurodegenerative disease management.

Main Methods:

• Systematic literature search of PubMed and Web of Science databases.
• Inclusion of 42 selected publications reporting on copper radionuclides for brain disease diagnosis or therapy.

Main Results:

• Copper isotopes (60Cu, 61Cu, 62Cu, 64Cu, 67Cu) have been investigated for various brain conditions.
• 64Cu and 67Cu show theranostic potential, with 64Cu having better availability.
• 60Cu, 61Cu, and 62Cu are mainly used for diagnostics.

Conclusions:

• 64Cu demonstrates significant potential as a theranostic agent for brain diseases.
• Further clinical research is essential to validate the therapeutic efficacy and safety of 64Cu in neurological conditions.