Related Experiment Video
Updated: Sep 9, 2025

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
Published on: September 19, 2012
A Break from the Norm? Parametric Representations of Preference Heterogeneity for Discrete Choice Models in Health
John Buckell1, Alice Wreford2, Matthew Quaife3
1Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Abstract:
BackgroundAny sample of individuals has its own unique distribution of preferences for choices that they make. Discrete choice models try to capture these distributions. Mixed logits are by far the most commonly used choice model in health. Many parametric specifications for these models are available. We test a range of alternative assumptions and model averaging to test if or how model outputs are affected.DesignScoping review of current modeling practices. Seven alternative distributions and model averaging over all distributional assumptions were compared on 4 datasets: 2 were stated preference, 1 was revealed preference, and 1 was simulated. Analyses examined model fit, preference distributions, willingness to pay, and forecasting.ResultsAlmost universally, using normal distributions is the standard practice in health. Alternative distributional assumptions outperformed standard practice. Preference distributions and the mean willingness to pay varied significantly across specifications and were seldom comparable to those derived from normal distributions. Model averaging offered distributions allowing for greater flexibility and further gains in fit, reproduced underlying distributions in simulations, and mitigated against analyst bias arising from distribution selection. There was no evidence that distributional assumptions affected predictions from models.LimitationsOur focus was on mixed logit models since these models are the most common in health, although latent class models are also used.ConclusionsThe standard practice of using all normal distributions appears to be an inferior approach for capturing random preference heterogeneity. Implications. Researchers should test alternative assumptions to normal distributions in their models.HighlightsHealth modelers use normal mixing distributions for preference heterogeneity.Alternative distributions offer more flexibility and improved model fit.Model averaging offers yet more flexibility and improved model fit.Distributions and willingness to pay differ substantially across alternatives.
Related Concept Videos
Models of Health Promotion and Illness Prevention I
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Parametric Survival Analysis: Weibull and Exponential Methods
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Analysis of Population Pharmacokinetic Data

