Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Upstream Processing01:27

Upstream Processing

97
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
97

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stretchable multimodal deformation sensor with self-mode recognition by a single Hall sensor.

Nature communications·2026
Same author

Physically intelligent capsule robots with embodied memory and logic in the gastrointestinal tract.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Optical fibre gripper for high-performance 3D micromanipulation.

Nature·2026
Same author

In vivo dynamic hotspot-enhanced Raman spectroscopy via reconfigurable swarming nanoprobes.

Nature communications·2026
Same author

Microswarm bridging effect for dual-surface biofilm eradication in submillimeter infection pockets.

Science advances·2026
Same author

Soft robotic devices for cardiovascular medicine.

Nature reviews. Cardiology·2026

Related Experiment Video

Updated: May 5, 2026

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

4.2K

Robotic micromanipulation for patterned and complex organoid biofabrication.

Mingsi Tong1, Gang Huang1, Songlin Zhuang2

  • 1Research Institute of Intelligent Control and Systems, Harbin Institute of Technology, Harbin, China.

Science Advances
|September 5, 2025
PubMed
Summary

This study introduces a micromanipulation platform for advanced organoid biofabrication. The system ensures consistent cell distribution, enabling complex organoid and assembloid manufacturing for research and drug screening.

More Related Videos

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
09:56

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

1.7K
A High-Throughput Platform for Culture and 3D Imaging of Organoids
07:42

A High-Throughput Platform for Culture and 3D Imaging of Organoids

Published on: October 14, 2022

3.1K

Related Experiment Videos

Last Updated: May 5, 2026

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

4.2K
Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
09:56

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

1.7K
A High-Throughput Platform for Culture and 3D Imaging of Organoids
07:42

A High-Throughput Platform for Culture and 3D Imaging of Organoids

Published on: October 14, 2022

3.1K

Area of Science:

  • Biotechnology and Bioengineering
  • Stem Cell Biology and Regenerative Medicine
  • Tissue Engineering and Biomaterials

Background:

  • Organoids are valuable models for studying tissue physiology and pathology.
  • Challenges in organoid manufacturing include lack of standardization and quality control.
  • Inconsistent cell distribution within extracellular matrices hinders organoid applications.

Purpose of the Study:

  • To develop a micromanipulation platform for patterned and complex organoid biofabrication.
  • To enable consistent self-assembly of multiple cell types within organoids.
  • To advance organoid-based research, drug screening, and biomechanism discovery.

Main Methods:

  • Utilized a micromanipulation platform for precise cell distribution control.
  • Integrated multidimensional cell sense technology for real-time feedback.
  • Implemented adaptive fluid dynamics control to manage fluidic perturbations during seeding.

Main Results:

  • Achieved robust control over spatial distribution of multiple cell types.
  • Demonstrated programmable organoid manufacturing with consistent self-assembly.
  • Successfully constructed assembloids mimicking mature organ microenvironments.

Conclusions:

  • The micromanipulation platform overcomes key challenges in organoid manufacturing.
  • This technology facilitates the creation of complex, multi-cellular organoid models.
  • Enables advancements in organoid applications for disease modeling and drug discovery.