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Updated: Sep 8, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Engineered VTA dopaminergic neurons offer a new path to treating depression
1Department of Psychology, Sapienza University, via dei Marsi 78, 00185 Rome, Italy; IRCCS San Raffaele, via di Val Cannuta 247, 00166 Rome, Italy.
Abstract:
Dysfunction of A10 midbrain dopaminergic (mDA) neurons is linked to psychiatric disorders, such as depression. In this issue, Yan et al.1 present an efficient method for differentiating human pluripotent stem cells into A10-like mDA neurons. Activation of grafted A10-like neurons into the mouse mesolimbic circuit alleviates depression-like symptoms.
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