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Updated: May 5, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

Water-insensitive down-shifting nanoparticles for sensitive biosensing.

Jiang Ming¹, Sikun Hu¹, Fan Zhang²

¹Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University, Shanghai, 200433, China.

Light, Science & Applications

|September 5, 2025

Summary

This summary is machine-generated.

Newly developed water-insensitive nanoparticles offer stable, high-contrast signals in aqueous environments. This enables highly sensitive avian influenza virus detection using low-power assays, even in opaque samples.

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Area of Science:

Nanotechnology
Biomedical Engineering
Infectious Disease Diagnostics

Background:

Conventional optical probes face signal degradation in aqueous environments, limiting biodetection sensitivity.
Existing methods for detecting avian influenza virus (AIV) can be hindered by opaque biological matrices and interference from visible-range signals.

Purpose of the Study:

To develop and evaluate water-insensitive down-shifting nanoparticles (WINPs) for enhanced biodetection.
To demonstrate the utility of WINPs in a low-power lateral flow assay for sensitive AIV detection in challenging sample types.

Main Methods:

Synthesis and characterization of water-insensitive down-shifting nanoparticles (WINPs) with near-infrared I (NIR-I) window emission.
Development of a low-power lateral flow assay utilizing WINPs as signal probes.
Testing the assay's performance for avian influenza virus (AIV) detection in opaque avian swab samples.

Main Results:

WINPs exhibit superior photophysical properties in aqueous media, including high quantum yield and minimal thermal effects.
The developed low-power lateral flow assay demonstrates high sensitivity and contrast for AIV detection.
The assay effectively mitigates interference issues common with visible-range signals and performs well in opaque matrices.

Conclusions:

Water-insensitive nanoparticles provide a robust platform for stable, high-contrast signal generation in biodetection assays.
Low-power lateral flow assays employing WINPs offer a promising approach for sensitive and reliable AIV diagnostics, even in complex biological samples.