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Related Concept Videos

Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language and Cognition01:27

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.

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Language Functional Connectivity Alterations During Resting State in Brain Arteriovenous Malformation Patients.

Xiaofeng Deng1,2, Qiji Shi3, Zekun Han1

  • 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

CNS Neuroscience & Therapeutics
|September 6, 2025
PubMed
Summary

Brain arteriovenous malformations (AVMs) can preserve language function through reorganized brain connectivity. This study reveals altered functional connectivity in AVM patients, highlighting compensatory mechanisms for intact language processing.

Keywords:
arteriovenous malformationfunctional connectivitylanguageresting statetrack‐weighted static functional connectivity

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Unruptured brain arteriovenous malformations (AVMs) rarely cause aphasia despite affecting dominant language areas.
  • Understanding the compensatory mechanisms for language function in AVM patients is crucial.

Purpose of the Study:

  • To investigate the language reorganization mechanisms in patients with unruptured brain arteriovenous malformations (AVMs) involving left-hemisphere language areas.
  • To analyze alterations in functional connectivity using functional connectivity (FC) and track-weighted static functional connectivity (TW-sFC).

Main Methods:

  • Cross-sectional study including 34 AVM patients and 27 healthy controls.
  • Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed.
  • Conventional FC and TW-sFC analyses were employed to assess gray and white matter connectivity.

Main Results:

  • AVM patients showed decreased FC between left and right hemisphere language regions.
  • Increased FC was observed between the anterior cingulate cortex (ACC) and cerebellar language areas.
  • TW-sFC revealed increased connectivity in right-hemisphere fiber bundles, left anterior thalamic radiation, and the corpus callosum.

Conclusions:

  • Intact language function in AVM patients may be attributed to inter-cerebral, cerebro-cerebellar, and intra-cerebral connection reorganization.
  • Reorganization involves reduced inter-hemispheric inhibition, cerebellar compensation via ACC, and enhanced perilesional function.
  • These findings elucidate the brain's remarkable plasticity in maintaining critical functions despite structural abnormalities.