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Immunofluorescence Microscopy

Immunofluorescence Microscopy

A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.
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Optically encoded microspheres in liquid-phase suspension array technology for immunoluminescence diagnostics: A

Jiuchuan Guo¹, Yiming Zhang¹, Bianzheng Wang²

¹School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.

Biosensors & Bioelectronics

|September 6, 2025

Summary

Liquid-phase suspension array technology (SAT) uses optically encoded microspheres for advanced biosensing. This method offers superior accuracy, speed, and multiplexing for high-throughput diagnostics.

Keywords:

Decoding instruments Luminescent immunodiagnostics Multiplexed detection Optically encoded microspheres Suspension array technology

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Area of Science:

Biomedical Engineering
Nanotechnology
Analytical Chemistry

Background:

Traditional immunoassays like ELISA have limitations in high-throughput and multiplexing.
Liquid-phase suspension array technology (SAT) utilizes optically encoded microspheres for advanced biosensing.
SAT offers advantages in accuracy, speed, sensitivity, and multiplex detection.

Purpose of the Study:

To provide a comprehensive overview of liquid-phase suspension array technology.
To review developments in optically encoded microspheres and decoding instruments.
To discuss current and future applications of SAT in diagnostics and biosensing.

Main Methods:

Review of advancements in optically encoded microspheres for SAT.
Analysis of various decoding instruments for suspension arrays.
Exploration of nanotechnology and nanomaterial integration in SAT.

Main Results:

Significant progress in multiplex analysis capacity, encoding efficiency, and detection sensitivity.
Demonstrated advantages over traditional methods in speed and accuracy.
Broadened application fields due to nanomaterial integration.

Conclusions:

SAT is a rapidly developing field with substantial potential in luminescent immunodiagnostics.
Future directions include novel nanomaterial integration and expanded application domains.
This technology is poised to enhance high-throughput biosensing and diagnostic capabilities.