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Optically encoded microspheres in liquid-phase suspension array technology for immunoluminescence diagnostics: A
Jiuchuan Guo1, Yiming Zhang1, Bianzheng Wang2
1School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Biosensors & Bioelectronics
|September 6, 2025
Summary
Liquid-phase suspension array technology (SAT) uses optically encoded microspheres for advanced biosensing. This method offers superior accuracy, speed, and multiplexing for high-throughput diagnostics.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Background:
- Traditional immunoassays like ELISA have limitations in high-throughput and multiplexing.
- Liquid-phase suspension array technology (SAT) utilizes optically encoded microspheres for advanced biosensing.
- SAT offers advantages in accuracy, speed, sensitivity, and multiplex detection.
Purpose of the Study:
- To provide a comprehensive overview of liquid-phase suspension array technology.
- To review developments in optically encoded microspheres and decoding instruments.
- To discuss current and future applications of SAT in diagnostics and biosensing.
Main Methods:
- Review of advancements in optically encoded microspheres for SAT.
- Analysis of various decoding instruments for suspension arrays.
- Exploration of nanotechnology and nanomaterial integration in SAT.
Main Results:
- Significant progress in multiplex analysis capacity, encoding efficiency, and detection sensitivity.
- Demonstrated advantages over traditional methods in speed and accuracy.
- Broadened application fields due to nanomaterial integration.
Conclusions:
- SAT is a rapidly developing field with substantial potential in luminescent immunodiagnostics.
- Future directions include novel nanomaterial integration and expanded application domains.
- This technology is poised to enhance high-throughput biosensing and diagnostic capabilities.
Keywords:
Decoding instrumentsLuminescent immunodiagnosticsMultiplexed detectionOptically encoded microspheresSuspension array technology
