Adopting novel alternative methods (NAMs) for biomedical research-What is the right approach?

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Updated: Sep 8, 2025

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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

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Clive N Svendsen1

  • 1Cedars-Sinai Board of Governors Regenerative Medicine Institute, 8700 Beverly Boulevard, Los Angeles, CA 90049, USA.

Cell Stem Cell
|September 6, 2025
PubMed
Abstract

No abstract available in PubMed .

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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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