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Advances in research on monogenic hereditary hypertension

Bingjie Guo1, Mengyuan Li1, Yingqing Feng2

  • 1Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine, Key Laboratory of Hereditary Rare Diseases of Health Commission of Henan Province, Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.

The American Journal of the Medical Sciences
|September 6, 2025
PubMed

Insights

Monogenic hypertension, a rare but significant condition, is increasingly understood through genetic research. Identifying specific gene mutations aids in comprehending its causes and developing targeted treatments.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Nephrology

Background:

  • Hypertension is a major global health risk, with monogenic hypertension representing a rare but important subtype.
  • Growing awareness necessitates a deeper understanding of monogenic hypertension's genetic underpinnings and clinical implications.

Purpose of the Study:

  • To categorize monogenic hypertension based on affected genes and pathophysiological mechanisms.
  • To highlight the impact of recent genetic advancements on understanding this condition.

Main Methods:

  • Review and classification of monogenic hypertension based on gene function and mutation type.
  • Analysis of recent findings in gene sequencing technology related to hypertension.

Main Results:

  • Monogenic hypertension is broadly classified into three categories: renal sodium transport, adrenal steroid, and other variants.
  • Identification of numerous pathogenic genes has advanced the understanding of disease mechanisms.

Conclusions:

  • Genetic research is crucial for elucidating monogenic hypertension's pathophysiology.
  • Advances in gene sequencing pave the way for novel therapeutic strategies for monogenic hypertension.

Keywords:
ClassificationGene mutationMechanismMonogenic hypertension

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