The role of the Hippo pathway in allergic diseases: Mechanisms and therapeutic potential

Allergic diseases, characterized by complex pathological mechanisms involving immune dysregulation and chronic inflammation, impose a substantial burden on global health. The Hippo signaling pathway, a highly conserved regulator of cell proliferation, apoptosis, immune homeostasis, and tissue repair, has recently emerged as a pivotal player in allergic disease pathogenesis. This review synthesizes current knowledge on the core components and physiological functions of the Hippo pathway, elucidates its mechanistic roles in major allergic disorders-including allergic asthma, allergic rhinitis, atopic dermatitis, and food allergies-and evaluates the therapeutic potential of targeting this pathway. By bridging molecular insights with clinical implications, we highlight how Hippo pathway modulation could pave the way for transformative treatments in allergy medicine.