[Interferon inhibition of the development of a staphylococcal infection]

Administration of interferon to mice with staphylococcal infection promoted elimination of the bacteria from their organs, influenced the immunological indices, normalized delayed type hypersensitivity, recovered the capacity of the spleen cells to produce interferon and increased the phagocytic activity of the peritoneal macrophages against the staphylococci. Addition of alpha-interferon to antibiotic therapy of patients with purulent septic infections of staphylococcal etiology markedly increased its efficiency. Improvement of the clinical picture of the disease, normalization of the general biochemical indices of the blood and elimination of the staphylococci from the blood and inflammation foci were observed.