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miRNA-494 in Lymphocytes: A Promising Biomarker for Acute Ischemic Stroke
Zixian Xie1, Ziping Han1, Tong Shen1
1Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053 Beijing, China.
Revista De Neurologia
|September 8, 2025
Summary
microRNA-494 (miRNA-494) levels in lymphocytes predict excellent outcomes for acute ischemic stroke (AIS) patients under 65. Higher miRNA-494 indicates milder stroke severity upon admission.
Area of Science:
- Neuroscience
- Biomarker Discovery
- Stroke Research
Background:
- Neuroinflammation is crucial in cerebral ischemia.
- microRNA-494 (miRNA-494) is implicated in neuroinflammation.
- The role of miRNA-494 as a biomarker for acute ischemic stroke (AIS) requires investigation.
Purpose of the Study:
- To evaluate miRNA-494 levels as a predictive biomarker for AIS severity.
- To assess miRNA-494 levels for predicting patient outcomes after AIS.
- To correlate miRNA-494 expression with stroke severity and prognosis.
Main Methods:
- Peripheral blood lymphocytes were analyzed for miRNA-494 expression using RT-qPCR.
- LASSO regression identified variables for logistic regression analysis.
- Univariate and multivariate logistic regression assessed associations between miRNA-494 levels, AIS severity (NIHSS), and outcomes (mRS).
Main Results:
- In patients under 65, high miRNA-494 predicted excellent AIS outcomes (mRS 0-1) (OR=2.800, p=0.028).
- Among these patients, miRNA-494 predicted excellent outcomes without recanalization therapy (continuous OR=8.938, p=0.010; categorical OR=5.200, p=0.013).
- Elevated miRNA-494 levels correlated with milder stroke severity on admission (continuous OR=2.586, p=0.044; categorical OR=3.514, p=0.004).
Conclusions:
- Increased miRNA-494 expression in lymphocytes predicts excellent outcomes in AIS patients under 65.
- Higher miRNA-494 levels are associated with reduced stroke severity at admission.
- miRNA-494 shows potential as a prognostic biomarker for acute ischemic stroke.
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