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Related Experiment Video

Updated: Jan 18, 2026

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
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Milk-Derived Injectable Wound Dressing with Sequential Photoactivatable Antibacterial Property through In Situ

Qinchao Zhu1, Xuhao Zhou1,2, Zhidan Wang1

  • 1Department of Cardiology The Second Affiliated Hospital School of Medicine Institute of Dairy Science College of Animal Sciences Zhejiang University Hangzhou 310009 China.

Small Science
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a green method for creating silver nanoparticles (AgNPs) within casein hydrogels. This novel material effectively treats infected wounds by promoting healing and regeneration.

Keywords:
antibacterial activitiesbiomineralizationcaseinsilver nanoparticleswound healing

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Disease Research

Background:

  • Rising antibiotic resistance necessitates alternative antibacterial strategies.
  • Inorganic nanoparticles, like silver nanoparticles (AgNPs), show broad-spectrum antibacterial properties.
  • Hydrogel dressings offer potential for wound healing applications.

Purpose of the Study:

  • To develop a "green" in situ synthesis of silver nanoparticles (AgNPs) within casein hydrogels.
  • To evaluate the antibacterial, photothermal, and wound healing properties of the developed casein-AgNP hydrogel.
  • To investigate the efficacy of sequential photoactivation for anti-infectious wound treatment.

Main Methods:

  • Simultaneous in situ synthesis of AgNPs during casein hydrogel photocrosslinking.
  • Sequential near-infrared laser activation for photothermal effect.
  • Assessment of hydrogel properties (swelling, mechanical, biocompatibility) and antibacterial activity.
  • In vivo animal studies to evaluate wound repair and tissue regeneration.

Main Results:

  • Casein-AgNP hydrogel demonstrated stability, antibacterial activity, and a significant photothermal effect.
  • The hydrogel exhibited low swelling, good mechanical properties, and excellent biocompatibility.
  • Animal experiments showed accelerated wound repair and tissue regeneration in infected wounds treated with casein-AgNP hydrogel.
  • The material effectively regulated immune response during healing.

Conclusions:

  • Sequential photoactivation is a promising strategy for developing anti-infectious wound treatments.
  • Casein hydrogels are suitable for in situ biomineralization and hold potential as advanced wound dressings.
  • The developed casein-AgNP hydrogel offers a novel approach to combatting bacterial infections and promoting wound healing.