[Improved estimation of parameters of blood pressure regulation in anesthetized dogs]

Estimation of parameters was based on tilting table tests in anaesthetized mongrel dogs. The registered variables were the carotid sinus pressure, aortic and superior vena cava pressure as well as the e.c.g. An orthostatic loading series after experimental designs of first order of Plackett and Burman served as an additional disturbance, which is necessary for a model in a closed loop system. Systemic parameters were estimated from measured data by means of recursive regression and generalized recursive regression. A discrepancy between the excellent animal tests and the quality of the model of subsequent estimation of parameters suggested a filtration of measured data, and a non-linear model (Hammerstein model) was selected for comparison. Contrary to the Hammerstein model, filtration of data led to a considerable improvement of the estimated parameters in the present study.