Related Experiment Video
Updated: Jan 18, 2026

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits
Published on: February 28, 2025
Genetics of Sudden Cardiac Arrest: Overview of Genetic Risk Factors and Aetiologies
Sarah Ming Li Tan1, Shir Lynn Lim1,2, Marcus Eh Ong3,4
1Department of Cardiology, National University Heart Centre Singapore Singapore.
None:
Sudden cardiac death (SCD) is one of the leading causes of death worldwide. Coronary artery disease (CAD) is the predominant cause of SCD in older individuals, while inherited cardiomyopathies and channelopathies are more common in younger individuals under the age of 35 years. Genetic disorders associated with SCD have traditionally been perceived as monogenic disorders. However, increasing evidence suggests that many of these disorders have complex genetic architecture with contributions from multiple genetic variants, known as polygenic inheritance, along with environmental factors. Improved understanding of genetic contributions and variants in SCD may help elucidate the cause of SCD, enable risk stratification, and identify novel disease mechanisms to guide preventative and therapeutic strategies in SCD. This review provides an overview of the genetic risk factors and clinical implications for the most common cardiac disorders related to SCD in both old and young individuals: specifically CAD, as well as the inherited cardiomyopathies and channelopathies, respectively.
More Related Videos
07:15Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
03:45Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Related Concept Videos
Mechanism of Cardiac Arrhythmias
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Electrophysiology of Normal Cardiac Rhythm
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Introduction Cardiac Emergencies
Coronary Artery Disease I: Introduction