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Associations Between Inflammatory and Catecholamine Markers and Clinical Outcomes in People with Post-Acute
Lynn H Gerber1,2, Micahel Estep1, Leyla De Avila1
1Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.
Post-acute SARS-CoV-2 infection (PASC) is linked to reduced well-being and increased fatigue. Biomarkers like epinephrine and Interleukin-1 beta may help track PASC recovery and inform treatment strategies.
Area of Science:
- Biochemistry
- Immunology
- Neuroscience
Background:
- Post-acute SARS-CoV-2 infection (PASC) presents with diverse and persistent health issues.
- Understanding the biological underpinnings of PASC is crucial for diagnosis and management.
Purpose of the Study:
- To investigate if cytokine, chemokine, or catecholamine levels can specify the clinical condition of PASC.
- To explore potential biomarkers for PASC severity and progression.
Main Methods:
- Seventy-nine participants with PASC were assessed for symptoms, comorbidities, and cognitive function.
- Patient-reported outcomes (PROs) including fatigue, quality of life, anxiety, and depression were collected.
- Levels of specific biomarkers, including epinephrine and Interleukin-1 beta (IL1b), were measured.
Main Results:
- PASC patients reported lower physical and emotional well-being, and higher fatigue levels compared to population norms.
- Epinephrine levels significantly correlated with fatigue, anxiety, and depression measures.
- Interleukin-1 beta (IL1b) showed inverse correlations with physical/emotional well-being and cognitive function.
Conclusions:
- Biomarkers such as epinephrine and IL1b may serve as objective measures for PASC.
- These findings suggest potential biological indicators for tracking PASC persistence or recovery.
- Further research is warranted to develop novel treatment approaches for PASC.
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