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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Hyperphosphorylated Tau Induces Cortical Hypoexcitability in Transgenic Mouse Models: A Meta-Analysis
Carlos A García-Carlos1, Gustavo Basurto-Islas2, George Perry3
1UNAM Division of Neurosciences, Institute of Cellular Physiology, National Autonomous University of Mexico, 04510 México City, México.
Journal of Integrative Neuroscience
|September 8, 2025
Summary
Hyperphosphorylated tau in Alzheimer's disease models alters brain activity, causing power decreases in neuronal oscillations. This suggests cortical network hypoexcitability, impacting cognitive function.
Area of Science:
- Neuroscience
- Pathology
- Biochemistry
Background:
- Neurofibrillary tangles from hyperphosphorylated tau are linked to Alzheimer's disease (AD) cognitive decline.
- Disrupted brain network activity is associated with AD-related cognitive deficits.
- Tau transgenic mouse models are used to study AD mechanisms, but network alterations vary.
Purpose of the Study:
- To assess oscillatory changes in tau transgenic models related to age and tau pathology.
- To analyze peak power and theta-gamma cross-frequency coupling (modulation index).
Main Methods:
- Systematic review of in vivo cortical local field potential recordings in tau transgenic mice (Jan 2002-Mar 2024).
- Meta-analysis adhering to PRISMA guidelines.
Main Results:
- Hyperphosphorylated tau correlated with decreased power in neuronal oscillations.
- Modulation index values showed no significant changes.
Conclusions:
- Neuronal oscillations in cortical networks are altered across AD pathology stages.
- Hyperphosphorylated tau accumulation is linked to cortical network hypoexcitability in tau models.
