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How to use the nautilus intrasaccular system.

Jeremy Lynch1,2, Francisco José Arruda Mont'Alverne3, J Mocco4

  • 1Department of Neuroradiology, Ruskin Wing, King's College Hospital NHS Foundation Trust, London, UK.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

The Nautilus intrasaccular system offers a low-profile endovascular solution for coiling brain aneurysms. Post-market data indicate high occlusion rates and low complications, especially for ruptured wide-necked aneurysms.

Keywords:
Aneurysmdeviceintrasaccular

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Area of Science:

  • Endovascular neurosurgery
  • Medical device technology
  • Cerebrovascular disease management

Background:

  • Intracranial aneurysms pose significant risks, necessitating effective treatment strategies.
  • Endovascular coiling is a common treatment, but challenges remain for wide-necked or ruptured aneurysms.
  • Intrasaccular devices offer novel approaches to aneurysm sac support during coiling.

Purpose of the Study:

  • To describe the Nautilus intrasaccular system, a novel endovascular device for intracranial aneurysm treatment.
  • To evaluate the feasibility, safety, and efficacy of the Nautilus system in clinical practice.
  • To highlight the device's potential utility in managing complex aneurysm morphologies.

Main Methods:

  • The Nautilus system is a spiral-shaped, neck-bridging device deployed via microcatheter.
  • Coils are delivered through the device struts, allowing for intrasaccular aneurysm sac support.
  • The device is constructed from nitinol and platinum, is radio-opaque, and mechanically detachable.

Main Results:

  • Limited data suggest high aneurysm occlusion rates with the Nautilus system.
  • Published series and post-market data report low complication rates.
  • The device's low profile and design may be advantageous for ruptured wide-necked aneurysms.

Conclusions:

  • The Nautilus intrasaccular system is a promising device for endovascular treatment of intracranial aneurysms.
  • It demonstrates favorable occlusion and complication rates in early clinical experience.
  • The system may be particularly beneficial for complex cases, including ruptured wide-necked aneurysms.