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Chronic Kidney Disease
Morgan E Grams1, Michal L Melamed1
1NYU Grossman School of Medicine, New York, New York (M.E.G., M.L.M.).
Annals of Internal Medicine
|September 8, 2025
Summary
Chronic kidney disease (CKD) affects 14% of Americans, impacting kidney, heart, and metabolic health. Recent medications offer new hope for slowing disease progression and preventing complications.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Metabolic Health
Background:
- 14% of Americans have chronic kidney disease (CKD), characterized by reduced glomerular filtration rate or albuminuria.
- CKD is often linked to diabetes and hypertension, but its complex interplay with cardiovascular and metabolic health is increasingly recognized.
- CKD progression can lead to severe metabolic issues and end-stage kidney disease, with cardiovascular events being a more frequent outcome.
Purpose of the Study:
- To outline the primary objectives of CKD management.
- To highlight recent therapeutic advancements in treating CKD.
- To emphasize the importance of addressing cardiovascular and metabolic aspects alongside kidney function.
Main Methods:
- Review of current understanding of CKD pathophysiology.
- Analysis of recent pharmacologic developments in CKD treatment.
- Synthesis of treatment goals for slowing CKD progression and preventing comorbidities.
Main Results:
- CKD management aims to preserve kidney function, mitigate cardiovascular risks, and manage metabolic disturbances.
- Emerging pharmacologic agents demonstrate efficacy in addressing multiple facets of CKD simultaneously.
- These advancements offer a more integrated approach to CKD care.
Conclusions:
- Integrated treatment strategies are crucial for managing CKD.
- Recent pharmacologic innovations provide effective options for comprehensive CKD management.
- Addressing cardiovascular and metabolic health is integral to effective CKD treatment.
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