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Published on: September 21, 2021
Cyclodextrin-metal-organic framework for encapsulating anthocyanins with the enhanced stability and antioxidant
Qimeng Su1, Shan Sun1, Shanghua Xing1
1State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.; Dalian Key Laboratory for Precision Nutrition, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
Abstract:
Anthocyanins (AC) are natural bioactive substances with the excellent antioxidant properties, but its structure is susceptible to the external environmental factors with inevitably decreased bioavailability. In this work, γ-cyclodextrin based metal-organic framework (CD-MOF) shows high encapsulation efficiency (96.09 %) and satisfiable loading amount (24.98 mg/g). Attributed to multiple hydrogen bonding and dispersion interactions between encapsulated AC and CD-MOF, CD-MOF could improve the AC stability against heating, irradiation and gastrointestinal digestion. Furthermore, the anti-oxidative stress effect of AC@CD-MOF was evaluated by using the model organism of Caenorhabditis elegans. AC@CD-MOF could prolong the lifespan, increase reproductive ability and improve the body length, by improving antioxidant enzyme activity and decreasing malondialdehyde content, ROS levels and lipofuscin accumulation. Compared to free AC, AC@CD-MOF showed the lower aging-induced oxidative stress. This work demonstrates the effective protection of AC by CD-MOF with improved antioxidative effect and provide a guidance for developing as anti-aging supplement.
