[Neurological complications associated with immune checkpoint inhibitors]

Area of Science:

• Neuro-oncology
• Immunotherapy
• Clinical Toxicology

Background:

• Immune checkpoint inhibitors (ICIs) are revolutionary cancer therapies.
• Immune-mediated adverse events are common with ICIs.
• Neurological toxicities pose significant clinical challenges.

Purpose of the Study:

• To review neurotoxic complications of immune checkpoint inhibitors.
• To inform clinicians about potential neurological side effects.
• To highlight the importance of vigilance in managing ICI therapy.

Main Methods:

• Literature review of clinical studies and case reports.
• Analysis of neurotoxicity incidence and presentation.
• Synthesis of current understanding of ICI-related neurotoxicity.

Main Results:

• Neurotoxicity affects both central and peripheral nervous systems.
• Common presentations include meningitis, encephalitis, and neuropathies.
• Early recognition and management are crucial for patient outcomes.

Conclusions:

• Immune checkpoint inhibitors can lead to diverse neurotoxicities.
• Clinicians require heightened awareness of these potential complications.
• Proactive monitoring and timely intervention are essential for safe ICI use.