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Updated: Jan 18, 2026
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[Progress on biologic therapies for severe asthma]
Z C Zhou1, H T Luo1, X Y Chen1
1Department of Allergy and Clinical Immunology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, Guangzhou 510120, China.
Abstract:
Biologics play a critical role in the treatment of severe bronchial asthma. Both Global initiative for asthma (GINA) and Guidelines for the prevention and management of bronchial asthma in our country recommend currently approved biologics as add-on therapies for patients whose symptoms remain uncontrolled despite high dose maintenance ICS-LABA treatments. The approved biologics include Omalizumab, Mepolizumab, Benralizumab, Reslizumab, Dupilumab, and Tezepelumab. These agents exert anti-inflammatory effects in asthma by targeting immunoglobulin E (IgE), interleukin-5 (IL-5) and its receptor IL-5R, IL-4Rα, and thymic stromal lymphopoietin (TSLP), respectively. This review categorized biologics based on their therapeutic targets, summarized those approved for severe asthma and briefly introduced agents currently under clinical investigation. It also discussed common challenges and future trends in biologic therapies. This review aimed to provide clinical and research insights for optimizing the application of biologics in asthma management.
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