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Updated: Jan 18, 2026
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
A Bifunctional Chiral Disulfide Catalyst for Highly Enantioselective Anti-Markovnikov Hydrophosphinylation
Lin Tang1, Shaoyu Hao1, Chaoren Shen1
1State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Abstract:
By the strategic integration of squaramide with amino acid derivatives, a type of modular H-bonding catalyst for the enantioselective hydrogen atom transfer (HAT) process was developed. With these disulfides, a photoinduced asymmetric anti-Markovnikov hydrophosphinylation was achieved, providing a series of chiral β-hydroxyphosphine oxides with reasonable to high enantioselectivity. Mechanism studies revealed the critical role of the H-bonding interactions between the squaramide scaffold and radical intermediates in governing the enantioselectivity and catalytic reactivity.
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