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Coagulation Disorders in Patients With Acute Respiratory Distress Syndrome Following Acute Aortic Dissection: A
Maomao Liu1, Tengke Wang1, Yan Yu1
1Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Reviews in Cardiovascular Medicine
|September 10, 2025
Summary
Coagulation activation from acute type A aortic dissection and cardiopulmonary bypass may cause acute respiratory distress syndrome. Elevated fibrin degradation products and altered factor XII levels are linked to ARDS development post-surgery.
Area of Science:
- Cardiovascular Surgery
- Pulmonary Medicine
- Hematology
Background:
- Coagulation disorders are a significant factor in the pathogenesis of acute respiratory distress syndrome (ARDS) following acute type A aortic dissection (ATAAD).
- Investigating the role of aortic dissection and cardiopulmonary bypass (CPB) in activating coagulation pathways is crucial for understanding ARDS development in ATAAD patients.
Purpose of the Study:
- To determine if aortic dissection and CPB activate coagulation pathways in ATAAD patients.
- To explore the relationship between coagulation biomarkers and ARDS development post-ATAAD.
Main Methods:
- A prospective cohort study of 450 patients with ATAAD, aortic aneurysm (AA), or unstable angina (UA).
- Analysis of clinical factors and serum coagulation biomarkers using ELISA.
- Logistic regression, ANOVA, and Spearman's correlation were employed for statistical analysis.
Main Results:
- The incidence of postoperative ARDS was 20.7% in ATAAD patients.
- Elevated D-dimer, FDPs, factor XIIa, and FVIII-Ag were observed in ATAAD patients.
- Higher FDP levels post-surgery and a negative correlation between factor XII and oxygenation index were found in the ARDS group.
Conclusions:
- Aortic dissection and CPB can activate coagulation, contributing to ARDS in ATAAD patients.
- Coagulation pathway activation is a key mechanism in the development of ARDS after ATAAD.
Keywords:
acute aortic dissectionacute respiratory distress syndromecardiopulmonary bypasscoagulationfibrinolysisMore Related Videos
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