Box of Lessons: An Open Educational Resource for Exploring Biomolecular Structure and Function

Structure-function relationships are a core concept in many STEM disciplines. Most biology curricula introduce students to macromolecules, their building blocks, and other small molecules that play key roles in biological processes. However, the shapes, interactions, and functions of these molecules are often discussed using schematic diagrams, ignoring the vast amounts of three-dimensional structural and bioinformatics data freely available from public data resources. Keeping up with and incorporating the rapidly evolving data, tools, and resources in suitable, structure-function focused lessons can be time-consuming and challenging. A group of experienced biology, chemistry, and biochemistry educators collaboratively developed the "Box of Lessons" (BOL) to engage students and educators in authentic explorations, reinforcing disciplinary concepts, while developing skills in biomolecular visualization and use of public bioinformatics data resources and tools. The BOL consists of multimedia learning materials, ready-to-use, student- and educator-facing worksheets with teaching notes, aligned with ASBMB learning goals. Materials in this collection have been reviewed and piloted by undergraduate educators before its publication on PDB-101, as modular open educational resources. Educators are encouraged to select BOL elements relevant to their curricular context and adapt them to fit their students' needs and learning goals.