Brugada ECG Pattern in A Caucasian Patient with Severe Hypothyroidism

Area of Science:

• Cardiology
• Endocrinology

Background:

• Brugada syndrome (BrS) is a disorder characterized by potentially life-threatening ventricular arrhythmias in individuals with structurally normal hearts.
• The Brugada pattern, defined by specific ECG abnormalities without symptoms, can be triggered by conditions like hypothyroidism.
• While more prevalent in men of Asian descent, BrS prevalence varies across ethnicities.

Purpose of the Study:

• To report a case of a Caucasian male with severe hypothyroidism and a Brugada ECG pattern.
• To investigate the effect of hypothyroidism treatment on the Brugada ECG pattern.

Main Methods:

• Case report of a Caucasian male.
• ECG monitoring before and after treatment for severe hypothyroidism.

Main Results:

• The patient presented with a Brugada ECG pattern.
• Following the initiation of thyroid hormone replacement therapy, the Brugada ECG pattern normalized.
• This association, though previously described in limited cases, was observed to be reversible.

Conclusions:

• Hypothyroidism is a potential reversible trigger for the Brugada ECG pattern.
• Prompt initiation of replacement therapy can reverse the Brugada ECG pattern in hypothyroid patients.
• This case adds to the literature on the association between hypothyroidism and Brugada syndrome.