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BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy.

Anna-Thekla P Jäger1,2,3, Christopher J Steele3,4, Felix R Dreyer5

  • 1Charité Universitätsmedizin, Charité, Berlin, Germany (A.-T.P.J.).

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|September 10, 2025
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Summary
This summary is machine-generated.

Intensive language therapy improved language and mood in chronic poststroke aphasia patients. Changes in long-range temporal correlations (LRTC) in brain activity reflected these improvements, particularly in right hemisphere regions.

Keywords:
aphasiadepressionfractalslanguagemagnetic resonance imagingneuronal plasticitystroke

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Area of Science:

  • Neuroscience
  • Cognitive Rehabilitation
  • Brain Imaging

Background:

  • Chronic poststroke aphasia presents challenges in language deficits and depression.
  • Neural mechanisms underlying intensive language-action therapy are not fully understood.
  • Long-range temporal correlations (LRTC) in brain activity may relate to learning and depression.

Purpose of the Study:

  • Investigate changes in blood oxygenation level-dependent (BOLD) LRTC in response to intensive language-action therapy.
  • Examine the relationship between LRTC changes and improvements in language function and mood.
  • Identify brain regions involved in therapy-induced neuroplasticity.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to assess BOLD LRTC before and after therapy in 16 patients.
  • Passive reading fMRI paradigm and detrended fluctuation analysis were employed.
  • Statistical analyses included repeated measures ANCOVA and correlation analyses, controlling for age, lesion size, time poststroke, and therapy intensity.

Main Results:

  • Changes in LRTC correlated with improvements in language performance in right perisylvian, domain-general, and memory areas.
  • Depressive symptom changes were also associated with LRTC alterations in right perisylvian regions.
  • Age influenced LRTC changes, with younger patients showing reductions and older patients showing increases.

Conclusions:

  • LRTC changes during therapy reflect concurrent improvements in language and mood in chronic poststroke aphasia.
  • Right perisylvian and domain-general regions are crucial for neuroplasticity and language rehabilitation.
  • LRTC may serve as a biomarker for tracking therapy-induced neuroplasticity and highlights the link between cognitive and emotional recovery.