Recent Advances in the Isolation, Bioactivity, Biosynthesis, and Total Synthesis of Hamigerans

Area of Science:

• Marine natural products chemistry
• Organic synthesis
• Medicinal chemistry

Background:

• Hamigerans are diterpenoids from the marine sponge *Hamigera tarangaensis*.
• They possess unique 6-6-5 or 6-7-5 tricyclic skeletons.
• Hamigerans exhibit notable biological activities, attracting synthetic interest.

Purpose of the Study:

• To review isolation, biosynthesis, bioactivity, and total synthesis of hamigerans.
• To focus on synthetic studies published since 2013.
• To offer insights for future research on hamigerans.

Main Methods:

• Literature review of isolation and biosynthesis.
• Summary of reported bioactivities.
• Analysis of total synthesis strategies and achievements since 2013.

Main Results:

• Compilation of known hamigerans and their structural diversity.
• Overview of established biosynthetic pathways.
• Detailed summary of synthetic routes and challenges.
• Highlighting key biological activities and potential therapeutic relevance.

Conclusions:

• Significant progress in hamigeran total synthesis has been achieved.
• Further research can explore novel hamigeran analogs and applications.
• This review provides a comprehensive resource for researchers in marine natural products and synthetic chemistry.