Treatment of a Patient with Severe Rash Pain Secondary to Monkeypox Virus: A Case Report

The following case describes a multimodal analgesic approach for pain control in a patient with monkeypox (mpox) lesions.

A 48-year-old man presented with a positive mpox test, an inability to tolerate solid foods due to severe throat pain and painful oral lesions, and severe genital burning and rectal pain. The pain management team utilized a multimodal analgesia regimen, which included a viscous lidocaine mouth solution, lidocaine jelly for perineal pain, acetaminophen, ketorolac, gabapentin, and oxycodone. On the following day, he was able to tolerate solid food and reported significantly less pain with defecation and urination.

This case report introduces an effective multimodal approach for pain control of mpox related lesions, which utilizes viscous and/or jelly lidocaine, acetaminophen, gabapentin, nonsteroidal antiinflammatory drugs, such as ketorolac, and opioids, such as oxycodone.