Related Experiment Video
Updated: Jan 18, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Risk factors for persisting SARS-CoV-2 infection in patients with B-cell malignancies in the Omicron era: A
Zeno Pasquini1, Alice Toschi2, Dino Gibertoni3
1Infectious Diseases Unit, Department for Integrated Infectious Risk Management, IRCCS AziendaOspedaliero-Universitaria di Bologna, Bologna, Italy.
Objectives:
Patients with B-cell malignancies are at high risk of persisting SARS-CoV-2 infection, which may delay oncologic treatments and increase morbidity. We aimed to assess risk factors for persisting infection in this population.
Methods:
We conducted a multicenter retrospective study across five tertiary hospitals between January 1, 2022, and January 1, 2023. Adult patients with B-cell malignancies and SARS-CoV-2 infection were included. Persisting infection was defined as viral shedding ≥21 days with clinical and/or radiological signs. Risk factors were evaluated through multivariable logistic regression.
Results:
Among 307 patients, 26.1% developed persisting infection. The cohort included non-Hodgkin lymphoma (67.4%), chronic lymphocytic leukemia (19.2%), and Hodgkin lymphoma (9.1%). Independent risk factors included anti-cluster of differentiation 20 therapy (odds ratio [OR], 3.22; 95% confidence interval [CI], 2.37-4.39; P <0.001), and hospital admission at diagnosis (OR, 5.16; 95% CI, 2.37-12.45; P <0.001). Early therapy with nirmatrelvir/ritonavir (OR, 0.32; 95% CI, 0.19-0.54; P <0.001), remdesivir (OR, 0.26; 95% CI, 0.18-0.37; P <0.001), and sotrovimab (OR, 0.32; 95% CI, 0.15-0.67; P = 0.003) were protective. Mortality at 120 days was higher in the persisting group, though not statistically significant (12.5% vs 8.4%; P = 0.277).
Conclusions:
Our findings help define risk factors for persisting SARS-CoV-2 infection and support early treatment in patients with B-cell malignancies.
More Related Videos
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
06:03Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
Related Concept Videos
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Cancers Originate from Somatic Mutations in a Single Cell
Mechanisms of Retrovirus-induced Cancers
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Single Nucleotide Polymorphisms-SNPs