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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Jan 18, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Dermatologic Oncology: The Past 50 Years.

Erika Tvedten1, Tara Jennings1, Murad Alam2

  • 1Departments of Dermatology and Dermatologic Surgery, Cooper University Hospital, Camden, NJ.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|September 11, 2025
PubMed
Summary
This summary is machine-generated.

Dermatologic Surgery (DS) has significantly advanced dermatologic oncology over 50 years, publishing key research on common skin cancers like melanoma, basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (cSCC), as well as rarer tumors. DS serves as a vital platform for disseminating crucial findings in skin cancer research.

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Area of Science:

  • Dermatologic Oncology
  • Surgical Oncology
  • Cutaneous Malignancies

Background:

  • Dermatologic oncology has seen significant evolution over the past five decades.
  • Advances in diagnosis and treatment have impacted common (melanoma, BCC, cSCC) and rare (MCC, EMPD, DFSP) skin cancers.
  • Dermatologic Surgery (DS) has been integral to these developments.

Purpose of the Study:

  • To explore historical advancements in dermatologic oncology.
  • To focus on the evolution of treating melanoma, BCC, and cSCC.
  • To examine the role of DS in the progress of treating rare skin tumors like MCC, DFSP, and EMPD.

Main Methods:

  • A rapid review of literature from 1975 to 2025 was conducted.
  • Searches were performed on PubMed and the DS database using specific search terms for each skin cancer type.
  • Search strategies were refined to isolate dermatologic oncology within the dermatologic surgery literature.

Main Results:

  • From 1975-2025, DS published a significant percentage of articles on melanoma (26.5%), MCC (11.2%), EMPD (10.2%), and DFSP (24.2%).
  • DS also contributed to BCC (5.3%) and cSCC (4.7%) literature.
  • The volume of publications in dermatologic oncology has substantially increased over this period.

Conclusions:

  • Dermatologic Surgery (DS) has been pivotal in advancing dermatologic oncology.
  • DS acts as a key platform for disseminating research findings in skin cancer.
  • The field's research scope has broadened, with a notable rise in publication volume over 50 years.