Transcatheter closure of multiperforated atrial septal defect

Area of Science:

• Cardiology
• Interventional Cardiology
• Congenital Heart Disease

Background:

• Multi-fenestrated atrial septal defects (mASD) present unique diagnostic and therapeutic challenges.
• Transcatheter closure is a common treatment for atrial septal defects (ASDs).

Purpose of the Study:

• To compare the outcomes of transcatheter closure in patients with mASD versus single ASD.
• To evaluate the safety and feasibility of mASD closure.

Main Methods:

• Retrospective, single-center study of adult patients undergoing transcatheter ASD closure (October 2014 - October 2024).
• Data collected included demographics, echocardiography, hemodynamics, and 6-month follow-up.
• Patients were divided into mASD (n=12) and single ASD (n=55) groups.

Main Results:

• mASD patients were younger (42 vs 54 years) and more likely to have interatrial septal aneurysms (91% vs 27%).
• Multiple occlusion devices were more frequently used in the mASD group (34% vs 4%).
• Complications were rare (5.9%) with no events in the mASD group; procedural outcomes were comparable.

Conclusions:

• Transcatheter closure of mASD is a safe and feasible procedure.
• Clinical outcomes for mASD closure are similar to those for single ASD closure.