Sensitization to common food allergens in infants with food protein-induced allergic proctocolitis: A prospective...

Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-associated disease, although some evidence exhibits IgE sensitization in a minority of patients.

This study aimed to determine the prevalence of IgE sensitization to common foods using skin tests and assess milk outgrowing in infants with FPIAP over a 5-year follow-up period.

This prospective study included infants with FPIAP in 2017. Skin prick tests were done using commercial extracts of 11 common food allergens. Infants were followed for 5 years, and the resolution was established by successfully ingesting cow's milk.

Of 126 infants analyzed, 81 infants (40 boys and 41 girls) with FPIAP completed this study. The frequency of food sensitization was 32% to at least one of the applied food allergens. Cow's milk (13.6%), egg (13.6%), and beef (6.2%) were the most frequent allergens, respectively. In this study, 45.7% of the infants developed a tolerance to the milk by the age of 1 year, 77.1% by the age of 2, 91.3% by the age of 3, and 96.3% by the age of 4. The rate of sensitization to milk was significantly different based on the tolerance time of early onset and grated late start for cow's milk (P < 0.001).

This study suggests pointing out skin tests of infants with FPIAP for common food allergens because IgE-mediated sensitization can infer a greater chance of a persistent course of milk intolerance.