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Related Experiment Video

Updated: Jul 5, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

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Published on: December 2, 2016

How Rapidly Does the FAPI PET Signal Reverse Following Therapy? Assessing the FAPI PET Signal in Hypertensive Cardiac

Atefeh Hosseini¹, Elias Haj-Yehia², Sebastian Korste²

¹Department of Nuclear Medicine, Medical Faculty, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|September 11, 2025

Summary

Fibroblast Activation Protein Inhibitor (FAPI) PET imaging can track the dynamic changes of activated fibroblasts in the heart and liver. This noninvasive imaging method shows promise for assessing treatment responses in fibrotic conditions.

Keywords:

FAPI PET rapid therapy response monitoring signal reversibility

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Last Updated: Jul 5, 2026

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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

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Area of Science:

Nuclear Medicine
Cardiovascular Imaging
Fibrosis Research

Background:

Reactive fibrosis is a key driver of heart failure progression.
Current antifibrotic therapies lack noninvasive methods for assessing fibrosis regression.
Fibroblast Activation Protein Inhibitor (FAPI) PET shows potential for imaging active fibrosis.

Purpose of the Study:

To investigate FAPI PET's ability to track the transition of activated fibroblast activation protein (FAP)-positive fibroblasts to a FAP-negative phenotype.
To assess FAPI PET as a tool for monitoring antifibrotic treatment response.

Main Methods:

Mice received angiotensin-II/phenylephrine (Ang-II/PE) infusion to induce fibrosis.
Longitudinal ⁶⁸Ga-FAPI-46 PET/CT scans were performed.
FAPI uptake, cardiac function (echocardiography), fibrosis (histology), and FAP expression (immunohistochemistry) were assessed.

Main Results:

⁶⁸Ga-FAPI-46 uptake peaked in the myocardium at 1 week and in the liver at 2 weeks.
PET signal rapidly declined after Ang-II/PE withdrawal, correlating with reduced fibrosis.
Cardiac FAPI signal changes preceded functional myocardial changes.

Conclusions:

FAPI PET effectively visualizes dynamic changes in FAP expression, enabling rapid assessment of treatment responses targeting activated fibroblasts.
FAPI PET can detect early fibrosis in cardiac remodeling and may visualize cardiac cirrhosis.
This imaging modality holds promise for guiding antifibrotic therapies.