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Updated: Jan 18, 2026
![Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58491.jpg&w=3840&q=50)
Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
Published on: August 8, 2019
Lumbar Spine Bone MRI: A Radiation-Free Approach Utilizing CT-Like Imaging for Diagnosing Pars Defects in the
Franziska C S Altorfer1, Jenny J Yan2, Frederik Abel3
1From the Department of Spine Surgery (F.C.S.A., D.R.L.), Hospital for Special Surgery, New York, New York altorferf@hss.edu.
Background And Purpose:
This is a retrospective cohort study to assess the quality of a synthetic bone MRI protocol by using the spoiled GRE (SPGRE) sequence and determine its usability in detecting pars defects in adolescent patients for orthopedic surgeons and radiologists.
Materials And Methods:
This retrospective study included 30 adolescent patients with lumbar spondylolysis and low back pain. Patients underwent a clinical lumbar spine MRI at 3T that included a 3D SPGRE sequence; 5 patients also underwent a CT for comparison. An orthopedic spine surgeon and an attending radiologist analyzed inverted SGPR and CT images, assessing the presence of a lumbar pars defect and image quality using a 5-point Likert scale. The interreader agreement was calculated.
Results:
Thirty patients were identified with pars defects seen in all patients on the SPGRE MRI. Image quality scores on a 5-point Likert scale measured an overall average of 4.53 ± 0.60, corresponding to good to perfect image quality, with a substantial interrater agreement with a Gwet AC2 of 0.79 [0.71, 0.88], without significant difference between the orthopedic surgeon and the radiologist (orthopedic surgeon's score 4.50 ± 0.63, radiologist's score 4.53 ± 0.57; P = .91).
Conclusions:
A synthetic bone MRI protocol using SPGRE is a viable, nonionizing alternative to CT for visualizing pars defects in adolescent patients, providing sufficient image quality for radiologists and orthopedic surgeons.
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