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Updated: Jan 18, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ligand-Controlled Ni-Catalyzed Regiodivergent Hydroacylation of Unactivated Alkenes with Acyl Chlorides
Jimin Liang1, Zhetai Feng2, Yi Liu1
1Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China.
Abstract:
Herein, we report a ligand-controlled, amide-assisted, nickel-catalyzed regiodivergent hydroacylation of unactivated alkenes with readily available acyl chlorides. This strategy enables the efficient and selective synthesis of amino ketones with diverse regioselectivities, including α- and β-migratory insertion, as well as Markovnikov-type addition, all governed by ligand tuning. The reaction proceeds under mild conditions, exhibits broad functional group tolerance, and offers a straightforward and cost-effective approach to structurally diverse branched ketones.
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