Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

343
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
343
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

480
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
480
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

752
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
752
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

416
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
416
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

2.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.3K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

424
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
424

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Body Mass Index: Skeletal Muscle Mass as a Marker of Physiologic Reserve in Fontan Circulation.

Pediatric cardiology·2026
Same author

Utility of Direct Fick Cardiac Output in Patients with Left Ventricular Assist Devices.

Journal of cardiac failure·2026
Same author

Trends and Projections for Aortic Stenosis and Hypertension-Related Mortality Among Older Adults in the United States: A Retrospective Population-Based Analysis.

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2026
Same author

Bile Acids, Mitochondria, and Myocardial Stiffness: A Shared Mechanism in Fontan Circulation and Metabolic Dysfunction-Associated Steatotic Liver Disease.

Circulation. Heart failure·2026
Same author

Balloon Pulmonary Angioplasty for Treatment of Chronic Thromboembolic Pulmonary Hypertension: Statement From the BPA-CTEPH Alliance.

JACC. Cardiovascular interventions·2026
Same author

Beyond existence: Physiologic phenotyping of patent foramen ovale.

Kardiologia polska·2026

Related Experiment Video

Updated: Jan 18, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.0K

Addressing Diastolic Dysfunction in the Congenital Heart Population.

Ryan M Edwards1, Allison P Levin2, Richard A Krasuski2

  • 1Department of Medicine, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27705, USA. ryan.m.edwards@duke.edu.

Current Cardiology Reports
|September 12, 2025
PubMed
Summary

Diastolic dysfunction is common in congenital heart disease (CHD). Advanced imaging and tailored management are key for assessing and treating this growing population.

Keywords:
Congenital Heart DiseaseDiastolic DysfunctionEchocardiographyHeart FailureSingle VentricleTetralogy of Fallot

More Related Videos

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.9K
Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.5K

Related Experiment Videos

Last Updated: Jan 18, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.0K
Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.9K
Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.5K

Area of Science:

  • Cardiology
  • Congenital Heart Disease
  • Diastology

Background:

  • Diastolic dysfunction is increasingly recognized in the aging congenital heart disease (CHD) population.
  • Prevalence varies across different congenital lesions.

Purpose of the Study:

  • To review recent advances in evaluating diastolic dysfunction in CHD.
  • To discuss management considerations for this unique patient group.

Main Methods:

  • Review of current literature on diastolic dysfunction assessment in CHD.
  • Discussion of traditional and emerging non-invasive imaging techniques.
  • Analysis of management strategies tailored to individual lesions.

Main Results:

  • Non-invasive assessment applicability differs based on specific CHD lesion.
  • Echocardiography is suitable for systemic left ventricle lesions.
  • Advanced techniques like 4D-flow cardiac MRI and late gadolinium enhancement are useful for complex lesions.
  • Management includes surveillance, medication, lifestyle changes, and device therapy.

Conclusions:

  • Diastolic dysfunction is a significant concern in the expanding CHD population.
  • Individualized assessment and management are crucial.
  • Further research into lesion-specific mechanisms is needed for optimal intervention.