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Supragingival Plaque Microbial Signatures Between Radiation Related Caries and Common Caries
Rui-Huan Gan1, Jing Qu1, Li-Qing Lan1
1Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Radiation-related caries (RRC) show distinct microbial differences from common caries. Prevotella conceptionensis is identified as a key bacterium in RRC, linked to enhanced glucose metabolism.
Area of Science:
- Oral microbiology
- Dental caries research
- Microbiome analysis
Background:
- Radiation-related caries (RRC) present unique clinical features distinct from common caries.
- Understanding the microbial differences is crucial for targeted prevention and treatment strategies.
Purpose of the Study:
- To investigate and compare the microbial compositions of supragingival plaque in patients with RRC versus common caries.
- To identify specific bacterial species and functional pathways associated with RRC.
Main Methods:
- Supragingival plaque samples analyzed using 2bRAD-M sequencing and qRT-PCR.
- Microbial diversity, relative abundance, and composition were assessed.
- LEfSe, random forest, KEGG, and COG analyses were performed to identify differentially abundant species and functional pathways.
Main Results:
- Prevotella conceptionensis, Treponema vincentii, and Nanoperiomorbus species were enriched in RRC.
- P. conceptionensis was identified as a potential biomarker for RRC.
- RRC samples showed higher bacterial abundance, particularly in glucose metabolism pathways.
Conclusions:
- Distinct microbial signatures differentiate RRC from common caries.
- Prevotella conceptionensis is a specific pathogen linked to RRC.
- Enhanced microbial glucose metabolism and ferroptosis-mediated inflammation may underlie RRC pathogenesis.
