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The bite that binds: mosquito saliva mediates TLR2-driven flavivirus infection
Laura Willen1, Fabiano Oliveira1
1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA.
Trends in Parasitology
|September 12, 2025
Abstract
None:
Mosquito saliva modulates host immunity, enhancing viral spread and disease. Suzuki et al. propose a previously uncharacterized, TLR2-driven mechanism of immunomodulation that is conserved across mosquito genera and independent of flavivirus type. This flavivirus-agnostic pathway may represent a promising target against mosquito-borne viral infections.

