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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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RETRACTED: Zhang et al. A Novel Framework for Reconstruction and Imaging of Target Scattering Centers via Wide-Angle Incidence in Radar Networks. <i>Sensors</i> 2025, <i>25</i>, 6802.

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Updated: May 1, 2026

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

Published on: December 14, 2009

Chip-Sized Lensless Holographic Microscope for Real-Time On-Chip Biological Sensing.

Sofía Moncada-Madrazo^1,2, Sergio Moreno^1,2, Oriol Caravaca^1,2

¹Department of Electronic and Biomedical Engineering, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.

Sensors (Basel, Switzerland)

|September 13, 2025

Summary

This summary is machine-generated.

Researchers developed a compact, affordable chip-sized lensless holographic microscope (CLHM) for continuous, in situ biological monitoring. This portable device overcomes traditional microscopy limitations for diverse applications.

Keywords:

angiogenesis compact microscope fermentation holography lab-on-a-chip lensless real-time monitoring zebrafish

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Last Updated: May 1, 2026

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

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Published on: December 14, 2009

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Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

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Published on: August 16, 2012

Area of Science:

Biotechnology
Optical Engineering
Microscopy

Background:

Conventional microscopy is essential but limited by manual operation, size, and complexity for continuous, in situ studies.
Existing microscopes are often impractical for field or on-platform experimentation due to their bulk and operational requirements.

Purpose of the Study:

To introduce a novel, compact, affordable, and portable microscope for continuous in situ biological monitoring.
To overcome the limitations of traditional microscopes regarding size, portability, and continuous operation.

Main Methods:

Development of a chip-sized lensless holographic microscope (CLHM) using a micro-LED display and CMOS sensor.
Enclosure of components within a 3D-printed housing for a compact and portable design.
Achieving a resolution of 2.19 μm with a 7 mm source-to-camera distance.

Main Results:

Demonstrated the CLHM's capability for continuous in situ monitoring directly on biological samples.
Successfully monitored in vitro models and performed morphological analyses of small whole organisms.
Achieved high resolution in a remarkably small form factor.

Conclusions:

The CLHM offers a versatile, on-platform sensing solution for continuous biological monitoring.
Its compact and portable design makes it suitable for diverse in situ applications.
This technology has the potential to significantly advance real-time biological research and diagnostics.